Understanding how epigenetic factors affect skin stem cell aging
Official title: Identifying epigenetic factors in control of epidermal stem cell longevity in the adult skin
Funded at Icahn School of Medicine at Mount Sinai · NIH-10881892 · Data updated 2026-11-12
This study is looking at how changes in skin stem cells as we age affect our skin's ability to heal and stay healthy, which could help us understand and improve issues like hair loss and slow healing.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 5, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $106,164 |
| NIH project number | 5K99AR082956-02 |
| Project ID | NIH-10881892 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults experiencing skin aging symptoms, such as thinning skin, hair loss, or delayed wound healing.
✕Less likely to help
Patients with acute skin injuries or conditions unrelated to aging may not benefit from this research.
What this research studies
This research investigates the role of epigenetic factors in the aging of skin stem cells, which are crucial for skin renewal and repair. By examining how these stem cells lose their function over time, the study aims to uncover the underlying mechanisms that contribute to skin aging and related conditions such as hair loss and delayed wound healing. The researchers will utilize advanced techniques to analyze changes in gene regulation and chromatin structure in skin cells. This could lead to new insights into maintaining skin health and longevity.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance skin regeneration and combat aging-related skin issues.
How similar studies have gone: Previous studies have shown promising results in understanding epigenetic mechanisms in aging, but this specific approach in mammalian skin is relatively novel.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Flora, Pooja — Icahn School of Medicine at Mount Sinai
- Study coordinator: Flora, Pooja
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.