Understanding how epigenetic changes affect skin health and cancer prevention
Epigenetic enhancer control in maintaining homeostasis and preventing carcinogenesis in the epidermis
This study is looking at how changes in skin cells might lead to conditions like actinic keratosis and skin cancer, and it’s for anyone interested in understanding more about skin health and potential new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10873862 on NIH RePORTER |
What this research studies
This research investigates the role of epigenetic changes in skin cells, particularly how these changes can lead to skin conditions like actinic keratosis and potentially skin cancer. By examining human skin samples and using advanced mouse models, the study aims to uncover the mechanisms by which epigenetic dysregulation contributes to skin cancer development. The researchers will employ innovative techniques to analyze chromatin modifications and their effects on cellular function, which could lead to new therapeutic strategies for maintaining skin health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with actinic keratosis or those with a history of significant sun exposure.
Not a fit: Patients with skin conditions unrelated to epigenetic changes or those who do not have a history of sun exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent skin cancer and improve skin health for patients at risk.
How similar studies have performed: Other research has shown promising results in understanding epigenetic modifications in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Capell, Brian — University of Pennsylvania
- Study coordinator: Capell, Brian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.