Understanding how epigenetic changes affect germ cell development
Official title: Determining cis- and trans- regulatory mechanisms of epigenetic bivalency
Funded at Yale University · NIH-10914680 · Data updated 2026-11-12
This study is looking at how certain changes in our genes help germ cells, which are important for making babies, stay flexible enough to develop into different types of cells while still keeping their potential for growth.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 30, 2022 |
| Project end | September 29, 2025 |
| Funding year | 2024 |
| Award (this year) | $33,892 |
| NIH project number | 5F31HD107950-03 |
| Project ID | NIH-10914680 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals experiencing infertility or developmental issues related to germ cell function.
✕Less likely to help
Patients with conditions unrelated to germ cell biology or those not seeking fertility treatments may not benefit from this research.
What this research studies
This research investigates the complex mechanisms that regulate epigenetic bivalency in germ cells, which are crucial for the development of offspring. By utilizing advanced CRISPR techniques, the study aims to identify the molecular factors that maintain the balance between gene activation and repression in these cells. This understanding could provide insights into how germ cells retain their potential for development while also differentiating into specific cell types. The research focuses on the role of specific histone modifications that influence gene expression during early development.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in reproductive health and developmental biology, potentially improving fertility treatments and understanding developmental disorders.
How similar studies have gone: Previous research has shown promising results in understanding epigenetic mechanisms using CRISPR technology, indicating that this approach has potential for success.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Marshall, Kira — Yale University
- Study coordinator: Marshall, Kira
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.