Understanding how epicardial cells influence heart muscle function
Epicardial regulation of cardiomyocyte function via modulation of extracellular signals: toward a model of human muscle pump function
This study is looking at how special heart cells can help improve the growth and function of heart muscle cells made from human stem cells, using a 3D printed model to better understand how to repair and regenerate heart tissue, which could lead to better treatments for heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10874481 on NIH RePORTER |
What this research studies
This research investigates the role of epicardial cells in enhancing the function and maturity of heart muscle cells derived from human stem cells. By creating a 3D printed model of cardiac tissue that includes an epicardial layer, the study aims to uncover the signals that promote the growth and development of these heart cells. Patients may benefit from insights gained about heart tissue regeneration and repair, which could lead to improved treatments for heart diseases. The research utilizes advanced tissue engineering techniques to mimic natural heart development and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart diseases or conditions that affect heart function.
Not a fit: Patients with non-cardiac conditions or those who do not have any heart-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for heart disease by improving the regeneration of heart tissue.
How similar studies have performed: Other research in cardiovascular tissue engineering has shown promise, indicating that this approach could lead to significant advancements in heart disease treatment.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Ogle, Brenda M — University of Minnesota
- Study coordinator: Ogle, Brenda M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.