Understanding how Eph receptors help cells communicate
Official title: Molecular mechanisms of Eph receptor signaling
Funded at Ohio State University · NIH-10938787 · Data updated 2026-11-12
This study is looking at how certain proteins help cells talk to each other, which is important for our health, especially in conditions like cancer and brain diseases, using special tools to see how these proteins work in human cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $297,513 |
| NIH project number | 1R35GM154813-01 |
| Project ID | NIH-10938787 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to cell signaling abnormalities, particularly those with cancer or neurodegenerative diseases.
✕Less likely to help
Patients with conditions unrelated to cell signaling or those who do not have any known genetic or biochemical disorders may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind how Eph receptors, a type of protein involved in cell signaling, facilitate communication between cells. By utilizing advanced techniques such as optogenetics and single-molecule microscopy, the research aims to uncover the processes that regulate the clustering of these receptors, which is crucial for various biological functions. The study focuses on human cells and seeks to provide insights into how these mechanisms are linked to health conditions like cancer and neurodegeneration.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to cell communication, such as cancer.
How similar studies have gone: Previous research has shown promising results in understanding cell signaling mechanisms, making this approach both relevant and potentially impactful.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Belyy, Vladislav — Ohio State University
- Study coordinator: Belyy, Vladislav
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.