Understanding how Epac signaling affects kidney function and blood pressure
Official title: Significance of Epac signaling in renal Na+handling and hypertension
Funded at University of Texas Hlth Sci Ctr Houston · NIH-10948044 · Data updated 2026-11-12
This study is looking at how a specific signaling process in the kidneys affects salt and water balance, with the goal of finding new ways to help people with high blood pressure by targeting different systems that manage sodium.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 19, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $678,566 |
| NIH project number | 1R01DK136462-01A1 |
| Project ID | NIH-10948044 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from hypertension or those at risk of developing high blood pressure.
✕Less likely to help
Patients with normal blood pressure or those whose hypertension is not related to renal sodium handling may not benefit from this research.
What this research studies
This research investigates the role of Epac signaling in the kidneys, which is crucial for managing salt and water balance in the body. By examining how Epac isoforms influence sodium handling in different parts of the kidney, the study aims to develop new treatments for hypertension that target multiple sodium transport systems simultaneously. The researchers will use advanced techniques, including genetic modifications in animal models, to explore the effects of inhibiting Epac on blood pressure regulation. This approach could lead to more effective therapies for patients with high blood pressure.
Why it matters
Potential benefit: If successful, this research could lead to new, more effective treatments for hypertension that improve blood pressure control.
How similar studies have gone: Previous research has shown promising results in targeting sodium transport mechanisms for hypertension treatment, suggesting that this approach could be effective.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Pochynyuk, Oleh — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Pochynyuk, Oleh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.