Understanding how eosinophils affect nerve growth in asthma
Identifying mechanisms and reversibility of eosinophil-induced airway hyperinnervation in asthma
['FUNDING_R01'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-11019673
This study is looking at how certain white blood cells called eosinophils might help grow more nerves in the airways of people with asthma, which could explain why some patients feel more sensitive and have trouble breathing; the researchers also want to see if a specific treatment can help reduce this nerve growth.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11019673 on ClinicalTrials.gov |
What this research studies
This research investigates the role of eosinophils, a type of white blood cell, in increasing nerve density in the airways of asthma patients. By examining how eosinophils release proteins that promote nerve growth, the study aims to uncover mechanisms behind heightened sensitivity and bronchoconstriction in asthma. The researchers will also explore whether treatments can reverse this nerve growth in patients receiving an anti-IL5 antibody. This approach combines laboratory studies with patient biopsies to provide insights into asthma management.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with asthma who exhibit high levels of eosinophils and experience significant airway hyperresponsiveness.
Not a fit: Patients with asthma who do not have elevated eosinophil levels or those with other underlying respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate asthma symptoms by targeting nerve growth and sensitivity.
How similar studies have performed: Previous research has shown promising results in understanding the role of eosinophils in asthma, but this specific approach to nerve remodeling is relatively novel.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DRAKE, MATTHEW G. — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: DRAKE, MATTHEW G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.