Understanding how enzymes work with DNA and RNA
Mechanisms of DNA and RNA Transactions
This study is looking at how certain enzymes help make and fix DNA and RNA in different living things, like viruses and fungi, to find new ways to create anti-fungal medicines that can keep us healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11075272 on NIH RePORTER |
What this research studies
This research investigates the mechanisms and structures of enzymes involved in the synthesis, modification, and repair of nucleic acids like DNA and RNA. By using a variety of experimental techniques, including microbiology and biochemistry, the project aims to explore how these enzymes function in different organisms, from viruses to fungi. The findings could lead to the development of new anti-fungal drugs by identifying specific targets within these enzymes that are crucial for cell health.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from fungal infections or those at high risk for such infections.
Not a fit: Patients with viral or bacterial infections that do not involve fungal components may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new and more effective anti-fungal treatments.
How similar studies have performed: Other research has shown success in targeting similar enzyme mechanisms for drug development, indicating a promising avenue for breakthroughs.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Shuman, Stewart H — Sloan-Kettering Inst Can Research
- Study coordinator: Shuman, Stewart H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.