Understanding how enzymes work in real time
Official title: Time-resolved structural studies of enzyme catalysis and regulation
Funded at University of Nebraska Lincoln · NIH-11076647 · Data updated 2026-11-12
This study is looking at how certain enzymes work in real-time, especially those linked to brain diseases and antibiotics, to help us understand their structure and function better, which could lead to new treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Lincoln NIH-funded |
| Lab location | 1 site (Lincoln, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $366,090 |
| NIH project number | 5R35GM153337-02 |
| Project ID | NIH-11076647 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by neurodegenerative diseases or those with conditions related to enzyme deficiencies.
✕Less likely to help
Patients with unrelated health conditions or those not affected by enzyme-related disorders may not benefit from this research.
What this research studies
This research investigates the mechanisms of enzyme catalysis using advanced techniques that allow scientists to observe these processes as they happen. By employing time-resolved serial crystallography, researchers aim to capture the structural changes in enzymes at an atomic level, particularly focusing on cysteine-dependent enzymes related to neurodegeneration and antibiotic breakdown. The study combines experimental methods with computational simulations to explore the role of quantum mechanics in enzyme function, potentially leading to new insights into biochemical processes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diseases related to enzyme dysfunction, such as Parkinson's disease.
How similar studies have gone: Other research has shown promise in using time-resolved crystallography to study enzyme mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Nebraska Lincoln
Lincoln, United States Active
Researchers
- Principal investigator: Wilson, Mark a. — University of Nebraska Lincoln
- Study coordinator: Wilson, Mark a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.