Understanding how enzymes that cut DNA work
Molecular mechanisms of modular nuclease domains
This study is looking at special enzymes that help keep our DNA safe and healthy, which could lead to better treatments for conditions like Lynch syndrome and some cancers, as well as new antibiotics for bacterial infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10928112 on NIH RePORTER |
What this research studies
This research investigates the role of nucleases, enzymes that cut nucleic acids, in maintaining the integrity of DNA during processes like replication and repair. By studying how these enzymes are regulated and how they can be made more specific, the research aims to uncover mechanisms that could lead to new treatments for diseases linked to DNA damage, such as Lynch syndrome and certain cancers. The approach involves modeling nuclease activity using proteins involved in DNA repair, which could also lead to the development of new antibiotics targeting bacterial nucleases. This work is crucial for advancing our understanding of genetic diseases and improving therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Lynch syndrome, colorectal cancer, or other conditions related to DNA repair deficiencies.
Not a fit: Patients with conditions unrelated to DNA damage or those not affected by genetic predispositions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for genetic disorders and cancers associated with DNA damage.
How similar studies have performed: Previous research has shown promise in understanding nucleases and their roles in DNA repair, indicating that this approach could yield significant insights.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Manhart, Carol M — Temple Univ of the Commonwealth
- Study coordinator: Manhart, Carol M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.