Understanding how enzymes keep metabolism balanced
Official title: Toward a quantitative understanding of metabolic homeostasis
Funded at University of California Berkeley · NIH-11001133 · Data updated 2026-11-12
This study is looking at how enzymes help keep our body's energy and building blocks in balance, which is important for everyone, especially those with diabetes, heart issues, or cancer, as it could lead to new treatments to help them feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | January 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $397,238 |
| NIH project number | 5R35GM152114-02 |
| Project ID | NIH-11001133 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with metabolic disorders such as diabetes, cardiovascular diseases, or cancer.
✕Less likely to help
Patients with metabolic conditions that are not related to enzyme regulation may not receive benefit from this research.
What this research studies
This research aims to explore how enzymes regulate metabolic homeostasis, which is crucial for maintaining energy levels and building blocks necessary for cell function. By developing mathematical models and experimental methods, the project seeks to uncover the complex interactions between enzymes and metabolites that contribute to metabolic balance. Patients with conditions like diabetes, cardiovascular diseases, and cancer may benefit from insights gained through this research, as it could lead to new therapeutic strategies. The research will involve both in vitro experiments and live cell studies to validate the models developed.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for metabolic disorders that affect millions of patients.
How similar studies have gone: Previous research has shown promise in understanding metabolic pathways, but this approach aims to provide a novel and comprehensive understanding of metabolic homeostasis.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Titov, Denis Vasilievich — University of California Berkeley
- Study coordinator: Titov, Denis Vasilievich
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.