Understanding how enzymes interact with DNA using computer simulations
Official title: Computational Simulations of DNA Transaction Enzymes - Application and Development
Funded at University of Texas Dallas · NIH-11017703 · Data updated 2026-11-12
This study is exploring how certain enzymes work with DNA using advanced computer simulations, which will help us understand how to keep our DNA healthy and prevent diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Dallas NIH-funded |
| Lab location | 1 site (Richardson, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $387,616 |
| NIH project number | 5R35GM151951-02 |
| Project ID | NIH-11017703 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or diseases linked to DNA malfunction.
✕Less likely to help
Patients with conditions unrelated to DNA transactions or those not affected by enzyme dysfunction may not benefit from this research.
What this research studies
This research focuses on using advanced computer simulations to study the mechanisms of enzymes that interact with DNA. By employing techniques like molecular dynamics and quantum mechanical methods, the project aims to gain insights into how these enzymes function at an atomic level. This understanding is crucial because accurate DNA maintenance and repair are essential for preventing diseases. The research will also involve the development of specialized software to enhance the accuracy of these simulations.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of DNA-related diseases and potentially inform new therapeutic strategies.
How similar studies have gone: Previous research using computational simulations in enzyme studies has shown promising results, indicating that this approach is both valid and potentially impactful.
Where this research is happening
-
University of Texas Dallas
Richardson, United States Active
Researchers
- Principal investigator: Cisneros, Gerardo Andres — University of Texas Dallas
- Study coordinator: Cisneros, Gerardo Andres
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.