Understanding how enzymes and proteins involved in fat metabolism work
Structure and regulation of lipid metabolism and transport
This study is looking at important proteins that help our bodies manage fats, which could lead to new treatments for obesity, diabetes, and heart disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10895274 on NIH RePORTER |
What this research studies
This research investigates the molecular and structural functions of enzymes and proteins that are crucial for lipid metabolism and transport. It focuses on two key enzymes, lipin and phospholipase D, which play significant roles in the synthesis of triglycerides and the regulation of fat storage, insulin sensitivity, and cell proliferation. By examining how these enzymes are activated and regulated, the research aims to fill existing knowledge gaps that could lead to new therapeutic strategies for conditions like obesity, diabetes, and cardiovascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals affected by obesity, diabetes, or cardiovascular diseases.
Not a fit: Patients with metabolic disorders unrelated to lipid metabolism may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for obesity, diabetes, and cardiovascular diseases by improving our understanding of lipid metabolism.
How similar studies have performed: Previous research has shown promising results in understanding lipid metabolism, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Airola, Michael Virgil — State University New York Stony Brook
- Study coordinator: Airola, Michael Virgil
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.