Understanding how enzyme assemblies regulate metabolism
Official title: Structure and function of metabolic enzyme assemblies
Funded at University of Washington · NIH-11080941 · Data updated 2026-11-12
This study is looking at how certain groups of enzymes work together to help control metabolism, which is important for everyone’s health, and it aims to understand how these enzyme groups change when our bodies need different things.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $620,569 |
| NIH project number | 5R35GM149542-03 |
| Project ID | NIH-11080941 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with metabolic disorders or conditions related to enzyme deficiencies.
✕Less likely to help
Patients with stable metabolic conditions that do not involve enzyme activity issues may not benefit from this research.
What this research studies
This research investigates the structures and functions of enzyme assemblies that play a crucial role in regulating metabolism. By using advanced techniques like cryo-electron microscopy, the team aims to uncover how these assemblies adapt to changes in the environment and metabolic demands. The study focuses on two main types of structures: metabolic filaments and metabolons, which help control enzyme activity and metabolic processes. Through in vitro experiments, the researchers will explore the molecular mechanisms behind these assemblies and their impact on metabolic regulation.
Why it matters
Potential benefit: If successful, this research could lead to new insights into metabolic disorders and potential therapeutic targets for improving metabolic health.
How similar studies have gone: Previous research has shown promising results in understanding enzyme assemblies, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Kollman, Justin M — University of Washington
- Study coordinator: Kollman, Justin M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.