Understanding how environmental damage affects mitochondrial DNA repair
Repair of Environmentally Induced Mitochondrial DNA Damage
This study looks at how harmful substances in our environment can hurt the tiny powerhouses in our cells, called mitochondria, and how our bodies try to fix that damage, which could help us understand links to health issues like cancer and brain diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Alabama NIH-funded |
| Lab location | 1 site (Mobile, United States) |
| Project ID | NIH-10597039 on NIH RePORTER |
What this research studies
This research investigates how environmental toxins, such as heavy metals and chemicals, damage mitochondrial DNA and how the body repairs this damage. It focuses on the role of specific enzymes that help fix the DNA and how these enzymes interact with other proteins in the mitochondria. By studying these processes, the research aims to uncover the links between mitochondrial DNA damage, metabolic dysfunction, and diseases like cancer and neurodegenerative disorders. Patients may gain insights into how their exposure to environmental factors could impact their health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals exposed to environmental toxins or those with metabolic disorders.
Not a fit: Patients with no history of exposure to environmental toxins or those without metabolic dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for diseases linked to mitochondrial DNA damage.
How similar studies have performed: Other research has shown promising results in understanding mitochondrial DNA repair mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Mobile, United States
- University of South Alabama — Mobile, United States (Active)
Researchers
- Principal investigator: Prakash, Aishwarya — University of South Alabama
- Study coordinator: Prakash, Aishwarya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.