Understanding how environmental chemicals affect DNA and RNA
Chemical Biology of DNA and RNA Alkylation
This study is looking at how certain chemicals in our environment can harm our DNA and RNA, and it aims to understand how our cells try to fix that damage, which could help us find better ways to protect our health from these harmful substances.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-11064866 on NIH RePORTER |
What this research studies
This research investigates the effects of alkylating agents, which are chemicals found in the environment that can damage DNA and RNA. The study aims to uncover the molecular mechanisms behind how these agents cause harm to human health, particularly focusing on how cells respond to DNA damage and repair it. Researchers will explore the role of specific DNA polymerases in bypassing DNA lesions and the implications of RNA modifications in certain diseases. By examining these processes in cultured human cells, the research seeks to provide insights that could lead to better prevention strategies against health issues caused by environmental exposures.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been exposed to alkylating agents or are at risk of exposure due to environmental factors.
Not a fit: Patients who have no history of exposure to alkylating agents or related environmental chemicals may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and mitigating health risks associated with exposure to harmful environmental chemicals.
How similar studies have performed: Previous research has shown success in understanding DNA damage and repair mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Wang, Yinsheng — University of California Riverside
- Study coordinator: Wang, Yinsheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.