Understanding how enteroviruses replicate and cause disease
Host determinants of enterovirus RNA replication and in vivo neuropathogenesis
This study is looking at how certain viruses, like those that can cause polio and paralysis, make copies of themselves in our cells, and it focuses on a special protein that helps them do this, with the hope of finding new ways to treat these infections and help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11059220 on NIH RePORTER |
What this research studies
This research investigates how enteroviruses, which are responsible for diseases like poliomyelitis and acute flaccid paralysis, replicate within human cells. The study focuses on a specific protein, SETD3, which is crucial for the virus's ability to reproduce and cause illness. By using advanced techniques to identify cellular components that support viral replication, the research aims to uncover new treatment strategies for infections caused by these viruses. Patients may benefit from insights gained about how to inhibit these viruses and improve health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include children aged 0-11 years who are at risk for enterovirus infections or related complications.
Not a fit: Patients with enterovirus infections who are older than 11 years may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for enterovirus-related diseases, potentially reducing the incidence and severity of these infections in children.
How similar studies have performed: Previous research has shown success in targeting cellular components to inhibit viral replication, suggesting that this approach may yield promising results.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Carette, Jan E — Stanford University
- Study coordinator: Carette, Jan E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.