Understanding how enteroviruses infect the human intestinal cells
Enterovirus Infection of Polarized Intestinal Cells
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-10839844
This study is looking at how certain viruses, like Coxsackieviruses, infect the cells in our intestines and how our immune system responds to these infections, which could help us find better ways to treat related illnesses.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10839844 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which enteroviruses, such as Coxsackieviruses, infect the human intestinal epithelium. Using advanced three-dimensional cell models that mimic the human gut environment, the study aims to uncover how these viruses interact with intestinal cells and the role of the immune response in controlling infections. By exploring these interactions, the research seeks to provide insights into the structural and functional impacts of enterovirus infections on the gut. This work could lead to better understanding and potential treatments for enterovirus-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced enterovirus infections or related gastrointestinal disorders.
Not a fit: Patients with non-enterovirus related gastrointestinal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating enterovirus infections in patients.
How similar studies have performed: Previous research has shown promise in understanding viral infections through similar cell model approaches, indicating potential for success in this area.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COYNE, CAROLYN B — DUKE UNIVERSITY
- Study coordinator: COYNE, CAROLYN B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.