Understanding how enteroviruses affect human cells
Functional characterization of the enteroviral degradome
This study is looking at how enteroviruses, which can make you sick with things like stomach bugs or brain infections, change the way your body's cells work, and it's for anyone interested in understanding how these viruses affect our immune system and how we might fight them better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10870016 on NIH RePORTER |
What this research studies
This research investigates how enteroviruses, which can cause various diseases like gastroenteritis and encephalitis, alter the biology of infected human cells. By focusing on specific proteins targeted by enteroviral proteases, the study aims to uncover the mechanisms through which these viruses manipulate host cell functions. The researchers are using advanced methodologies, including human stem cell-derived intestinal epithelial cells, to explore the innate immune responses triggered during infection. This approach could lead to new insights into viral inhibition and immune activation.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with enterovirus infections or those at risk of developing related diseases such as encephalitis or myocarditis.
Not a fit: Patients with non-enteroviral infections or unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating enterovirus infections and related diseases.
How similar studies have performed: Previous research has shown promising results in understanding viral interactions with host cells, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Saeed, Mohsan — Boston University Medical Campus
- Study coordinator: Saeed, Mohsan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.