Understanding how enteric caliciviruses infect hosts.
Determinants of Enteric Calicivirus Infection.
This study is looking into how the human norovirus makes people sick with gastroenteritis, and it's for anyone interested in understanding how this virus works so we can find better ways to prevent infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m Agrilife Research NIH-funded |
| Lab location | 1 site (College Station, UNITED STATES) |
| Project ID | NIH-10876231 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind how human norovirus (HuNoV) causes gastroenteritis, a common and serious illness. By using a novel model based on rhesus enteric caliciviruses, the researchers aim to identify the specific host factors that allow these viruses to infect cells. The study employs advanced techniques like CRISPR-Cas9 for genome-wide screening to pinpoint these determinants, which could lead to better understanding and prevention of infections. The findings may help improve current methods for studying these viruses and their impact on human health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of norovirus infections, particularly those with weakened immune systems or underlying health conditions.
Not a fit: Patients who are not affected by norovirus or do not have any gastrointestinal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating norovirus infections in humans.
How similar studies have performed: Previous research has shown promise in using similar models to study viral infections, indicating potential for success in this approach.
Where this research is happening
College Station, UNITED STATES
- Texas A&m Agrilife Research — College Station, United States (Active)
Researchers
- Principal investigator: Farkas, Tibor — Texas A&m Agrilife Research
- Study coordinator: Farkas, Tibor
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.