Understanding how enhancers regulate gene activity
Official title: Dissecting enhancer function through integrative genomics
Funded at H. Lee Moffitt Cancer Ctr & Res Inst · NIH-10938828 · Data updated 2026-11-12
This study is looking at special parts of our DNA called enhancers that help control how genes work in different types of cells, and it's for anyone interested in understanding how these enhancers might affect health and diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | September 5, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $421,250 |
| NIH project number | 1R35GM155298-01 |
| Project ID | NIH-10938828 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or diseases that may be influenced by enhancer activity and gene regulation.
✕Less likely to help
Patients with conditions unrelated to genetic regulation or enhancer function may not benefit from this research.
What this research studies
This research investigates enhancers, which are non-coding elements that play a crucial role in controlling gene transcription specific to different cell types. By analyzing various features of enhancers across hundreds of human cell types, the research aims to overcome challenges related to data variability and the lack of consensus in functional evaluation. The approach combines advanced computational methods and machine learning to provide a comprehensive understanding of how enhancers influence gene regulation and contribute to human diseases. This could lead to better insights into the genetic basis of various conditions.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic regulation and potentially lead to new therapeutic strategies for diseases linked to enhancer dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding gene regulation through enhancer studies, indicating that this approach has potential for significant advancements.
Where this research is happening
-
H. Lee Moffitt Cancer Ctr & Res Inst
Tampa, United States Active
Researchers
- Principal investigator: Teng, Mingxiang — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Teng, Mingxiang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.