Understanding how enhancers control gene activity in cells
Official title: Mechanisms of enhancer dynamics and assembly in gene regulation
Funded at University of Texas Hlth Science Center · NIH-11053593 · Data updated 2026-11-12
This study is looking at how certain parts of our DNA help control gene activity, especially when it comes to changes in our bodies during development and diseases like breast cancer, to find new ways to prevent and treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $387,508 |
| NIH project number | 5R35GM153228-02 |
| Project ID | NIH-11053593 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with breast cancer or other conditions influenced by enhancer dynamics.
✕Less likely to help
Patients with conditions unrelated to gene regulation or enhancer dynamics may not benefit from this research.
What this research studies
This research investigates the mechanisms by which enhancer regions of DNA regulate gene expression, particularly in response to various signals. It aims to understand how these enhancers change dynamically during different stages of tissue development and disease, such as breast cancer. By studying the organization of enhancer chromatin and the interactions that lead to enhancer assembly, the research seeks to uncover new strategies for preventing and treating diseases linked to enhancer dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for diseases related to enhancer dysfunction, improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding enhancer dynamics, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Liu, Zhijie "Jason" — University of Texas Hlth Science Center
- Study coordinator: Liu, Zhijie "Jason"
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.