Understanding how enhancers control gene activity in cells
Mechanisms of enhancer dynamics and assembly in gene regulation
This study is looking at how certain parts of our DNA help control gene activity, especially when it comes to changes in our bodies during development and diseases like breast cancer, to find new ways to prevent and treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11053593 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which enhancer regions of DNA regulate gene expression, particularly in response to various signals. It aims to understand how these enhancers change dynamically during different stages of tissue development and disease, such as breast cancer. By studying the organization of enhancer chromatin and the interactions that lead to enhancer assembly, the research seeks to uncover new strategies for preventing and treating diseases linked to enhancer dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with breast cancer or other conditions influenced by enhancer dynamics.
Not a fit: Patients with conditions unrelated to gene regulation or enhancer dynamics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for diseases related to enhancer dysfunction, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding enhancer dynamics, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Liu, Zhijie "Jason" — University of Texas Hlth Science Center
- Study coordinator: Liu, Zhijie "Jason"
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.