Understanding how enhancers control gene activity in cancer cells
Dynamics and mechanisms of long-range enhancer activity
['FUNDING_FELLOWSHIP'] · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · NIH-11070450
This study is looking at how certain parts of our DNA, called enhancers, help turn genes on and off in cancer cells, especially focusing on the MYC gene, to better understand how we might treat cancer in the future.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-11070450 on ClinicalTrials.gov |
What this research studies
This research investigates the role of enhancers, which are regulatory sequences that control when and where genes are activated, particularly in cancer cells. By using advanced imaging techniques, the study aims to visualize how these enhancers interact with genes over large distances in living cells. The focus is on the MYC gene, which is often overexpressed in certain cancers due to enhancer clusters. The findings could provide insights into the mechanisms of gene regulation and potential therapeutic targets for cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with lung or endometrial cancers that may be influenced by MYC enhancer activity.
Not a fit: Patients with cancers unrelated to MYC or those not expressing the relevant enhancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting gene regulation in cancer therapies.
How similar studies have performed: Previous research has shown promising results in understanding enhancer functions, but this specific approach using live-cell imaging is relatively novel.
Where this research is happening
CAMBRIDGE, UNITED STATES
- MASSACHUSETTS INSTITUTE OF TECHNOLOGY — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HONG, CLARICE KIT YEE — MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- Study coordinator: HONG, CLARICE KIT YEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.