Understanding how enhancer RNAs regulate gene expression and genome organization
Mechanisms Underlying Enhancer Rnp Mediated Gene Regulation And Genome Organization
This study is looking at how certain tiny molecules called enhancer RNAs help control genes and shape our DNA, which is important for how our cells work, and it aims to find out how these molecules interact with specific proteins in human cells to improve our understanding of potential new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10899530 on NIH RePORTER |
What this research studies
This research investigates the role of enhancer RNAs (eRNAs) in gene regulation and genome organization, which are crucial for determining cell identity and function. By developing innovative methods to identify the interactions between eRNAs and proteins in human cells, the study aims to uncover the molecular mechanisms that govern these processes. The research focuses on two specific proteins that bind to eRNAs, exploring their roles in gene transcription and the three-dimensional structure of the genome. This work could lead to new insights into how enhancer functions can be targeted for therapeutic purposes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or cancers associated with enhancer mutations or dysregulation.
Not a fit: Patients with conditions unrelated to enhancer function or those not affected by genetic mutations in enhancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies targeting enhancer functions, potentially improving treatment options for various diseases.
How similar studies have performed: Previous research has shown promising results in understanding enhancer functions, but this specific approach focusing on eRNA interactions is relatively novel.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Li, Wenbo — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Li, Wenbo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.