Understanding how engineered lung tissue affects cell behavior
Engineered alveolar organoids to understand ECM signaling
['FUNDING_OTHER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10685523
This study is looking at how the support structure around lung cells, called the extracellular matrix, affects the way these cells behave in people with idiopathic pulmonary fibrosis (IPF), with the hope of finding new ways to help improve lung health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10685523 on ClinicalTrials.gov |
What this research studies
This research investigates the role of extracellular matrix (ECM) in the development of idiopathic pulmonary fibrosis (IPF), a condition that affects lung function. By creating engineered alveolar organoids, the study aims to explore how changes in ECM influence the behavior of alveolar epithelial cells. The researchers will develop specific hydrogel matrices to create these organoids, allowing for controlled experiments to observe cell responses to ECM alterations. This approach seeks to uncover the mechanisms behind cell dysfunction in IPF, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with idiopathic pulmonary fibrosis or those at risk for developing this condition.
Not a fit: Patients with other forms of lung disease unrelated to idiopathic pulmonary fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with idiopathic pulmonary fibrosis.
How similar studies have performed: Previous research has shown promise in using organoid models to study lung diseases, indicating that this approach may yield valuable insights.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LOEBEL, CLAUDIA — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: LOEBEL, CLAUDIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.