Understanding how energy use in fat tissue is regulated
Regulating energy expenditure in adipose tissue
This study is looking at how our fat cells use energy when we eat too much or when we fast, focusing on a protein called TBK1 that might help our bodies decide whether to store or burn energy, with the hope that this could lead to better treatments for obesity and diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10867442 on NIH RePORTER |
What this research studies
This research investigates how energy expenditure in adipose tissue changes during periods of overeating and fasting. It focuses on a protein called TBK1, which may play a crucial role in how our bodies store or burn energy. By studying both mouse models and patients treated with a TBK1 inhibitor, the research aims to uncover the mechanisms behind these metabolic changes. The findings could lead to new treatments for obesity and diabetes by targeting energy regulation in fat cells.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults experiencing obesity or insulin resistance.
Not a fit: Patients with conditions unrelated to obesity or metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic strategies for managing obesity and diabetes.
How similar studies have performed: Other research has shown promising results in understanding metabolic regulation, making this approach both relevant and potentially impactful.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Saltiel, Alan R. — University of California, San Diego
- Study coordinator: Saltiel, Alan R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.