Understanding how energy production in cells affects aging
Official title: Multimodal control of mitochondrial energetics to shape biological aging
Funded at University of Rochester · NIH-10864185 · Data updated 2026-11-12
This study is looking at how the energy powerhouses in our cells change as we get older and how eating less might help keep them working well, which could lead to healthier aging.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $316,297 |
| NIH project number | 1R56AG082916-01 |
| Project ID | NIH-10864185 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in aging and longevity, particularly those who may benefit from dietary interventions.
✕Less likely to help
Patients with acute mitochondrial diseases or those not interested in dietary modifications may not benefit from this research.
What this research studies
This research investigates the role of mitochondrial function, specifically the protonmotive force (PMF), in the aging process. It examines how PMF varies with age and how dietary restrictions can help maintain PMF levels, potentially influencing longevity. The study will utilize model organisms like C. elegans and human cells to explore the mechanisms behind PMF changes and their impact on aging. By understanding these processes, the research aims to identify new strategies for promoting healthy aging.
Why it matters
Potential benefit: If successful, this research could lead to new interventions that promote healthier aging and potentially extend lifespan.
How similar studies have gone: Previous research has shown that dietary restrictions can positively influence mitochondrial function and longevity, suggesting that this approach has potential for success.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Wojtovich, Andrew Phillip — University of Rochester
- Study coordinator: Wojtovich, Andrew Phillip
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.