Understanding how energy production in cells affects aging
Multimodal control of mitochondrial energetics to shape biological aging
['FUNDING_OTHER'] · UNIVERSITY OF ROCHESTER · NIH-10864185
This study is looking at how the energy powerhouses in our cells change as we get older and how eating less might help keep them working well, which could lead to healthier aging.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10864185 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mitochondrial function, specifically the protonmotive force (PMF), in the aging process. It examines how PMF varies with age and how dietary restrictions can help maintain PMF levels, potentially influencing longevity. The study will utilize model organisms like C. elegans and human cells to explore the mechanisms behind PMF changes and their impact on aging. By understanding these processes, the research aims to identify new strategies for promoting healthy aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in aging and longevity, particularly those who may benefit from dietary interventions.
Not a fit: Patients with acute mitochondrial diseases or those not interested in dietary modifications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new interventions that promote healthier aging and potentially extend lifespan.
How similar studies have performed: Previous research has shown that dietary restrictions can positively influence mitochondrial function and longevity, suggesting that this approach has potential for success.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOJTOVICH, ANDREW PHILLIP — UNIVERSITY OF ROCHESTER
- Study coordinator: WOJTOVICH, ANDREW PHILLIP
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.