Understanding how energy depletion affects the heart during low oxygen conditions
Pathways of Succinate Accumulation and Adenine Nucleotide Depletion in Cardiac Ischemia
This study looks at how low oxygen levels affect the heart's energy and health, especially during heart attacks or when organs are moved, to find ways to better protect the heart when blood flow comes back.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10910211 on NIH RePORTER |
What this research studies
This research investigates how the heart's energy production is impacted during periods of low oxygen, such as in heart attacks or during organ transportation. It focuses on the accumulation of succinate and the depletion of adenine nucleotides, which are crucial for heart function. By studying these metabolic changes, the research aims to uncover the mechanisms behind heart damage when blood flow is restored after ischemia. This could lead to better strategies for protecting heart tissue during critical situations.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients experiencing ischemic heart disease or those undergoing heart transplantation.
Not a fit: Patients with non-cardiac conditions or those not experiencing ischemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for heart conditions related to oxygen deprivation, potentially reducing heart damage during heart attacks.
How similar studies have performed: Previous research has shown promising results in understanding metabolic changes during ischemia, indicating that this approach has potential for significant advancements.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Collins, Nicole — University of Michigan at Ann Arbor
- Study coordinator: Collins, Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.