Understanding how EndoU affects cell death and cancer development
Official title: Function and mechanism of EndoU
Funded at University of California Riverside · NIH-10982360 · Data updated 2026-11-12
This study is looking at a protein called EndoU to understand how it helps control cell death and its effects on different cancers, which could lead to new ways to treat these diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project start | September 15, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $376,876 |
| NIH project number | 1R01GM152548-01A1 |
| Project ID | NIH-10982360 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with uterine, cervical, skin, bronchial, lung, esophageal, oral squamous, or colorectal cancers.
✕Less likely to help
Patients with cancers not associated with EndoU misregulation or those without a cancer diagnosis may not benefit from this research.
What this research studies
This research investigates the role of a protein called EndoU, which is involved in the regulation of cell death and cancer. The study aims to uncover how EndoU functions at a molecular level, particularly how it is activated by calcium ions and its impact on various types of cancer. By examining EndoU's activity in cell cultures, researchers hope to clarify its role in cellular responses and its potential as a prognostic marker for certain cancers. This could lead to new insights into cancer biology and treatment strategies.
Why it matters
Potential benefit: If successful, this research could provide new targets for cancer therapies and improve prognostic assessments for patients with specific types of cancer.
How similar studies have gone: Previous research has shown promising results in understanding RNA-binding proteins and their roles in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Riverside
Riverside, United States Active
Researchers
- Principal investigator: Karginov, Fedor V — University of California Riverside
- Study coordinator: Karginov, Fedor V
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.