Understanding how endothelial cell dysfunction contributes to cerebral aneurysms
Endothelial cell dysfunction in cerebral aneurysm pathogenesis
['FUNDING_R01'] · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · NIH-10755655
This study is looking at how a substance called interleukin-2 affects the cells that line blood vessels in the brain, which could help us understand and find new ways to prevent or treat cerebral aneurysms.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MIAMI SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (CORAL GABLES, UNITED STATES) |
| Trial ID | NIH-10755655 on ClinicalTrials.gov |
What this research studies
This research investigates the role of endothelial cell dysfunction in the development of cerebral aneurysms, focusing on the inflammatory cytokine interleukin-2 (IL-2) and its effects on blood vessel cells. The study aims to understand how IL-2 activates a specific pathway that leads to changes in endothelial cell function, promoting inflammation and potentially leading to aneurysm formation. By using a mouse model, researchers will explore the impact of inhibiting this pathway on aneurysm progression and rupture. The ultimate goal is to identify new therapeutic strategies to prevent or treat cerebral aneurysms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for cerebral aneurysms, particularly those with a family history or other risk factors.
Not a fit: Patients who do not have cerebral aneurysms or significant risk factors for developing them may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the formation and progression of cerebral aneurysms, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways for vascular diseases, suggesting potential for success in this approach.
Where this research is happening
CORAL GABLES, UNITED STATES
- UNIVERSITY OF MIAMI SCHOOL OF MEDICINE — CORAL GABLES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STARKE, ROBERT MICHAEL — UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- Study coordinator: STARKE, ROBERT MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.