Understanding how endosomal defects contribute to neurodegenerative disorders like Alzheimer's disease
Official title: NHE6-mediated endosomal defects in neurodegenerative disorders
Funded at Brown University · NIH-10790010 · Data updated 2026-11-12
This study is looking into how problems with certain cell structures might contribute to Alzheimer's and similar diseases, using a special rat model to find new ways to help improve treatments for people living with these conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | March 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $117,853 |
| NIH project number | 5K99AG076868-02 |
| Project ID | NIH-10790010 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related neurodegenerative disorders.
✕Less likely to help
Patients with neurodegenerative disorders not related to endosomal dysfunction may not benefit from this research.
What this research studies
This research investigates the role of endosomal dysfunction in neurodegenerative disorders, particularly focusing on Alzheimer's disease and related dementias. The study aims to uncover the cellular mechanisms that lead to neurodegeneration, specifically through the lens of Na+/H+Exchanger 6 (NHE6) and its impact on endosomal function. By utilizing a novel rat model that better mimics the neurodegenerative features of these conditions, the research seeks to identify new therapeutic targets that could improve treatment options for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that target the underlying mechanisms of Alzheimer's disease and related dementias.
How similar studies have gone: Previous research has shown promising results in understanding endosomal pathways in neurodegeneration, suggesting that this approach could yield significant insights.
Where this research is happening
-
Brown University
Providence, United States Active
Researchers
- Principal investigator: Lee, Eugene Y — Brown University
- Study coordinator: Lee, Eugene Y
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.