Understanding how enamel proteins help form teeth
MATRIX BASED MINERAL ENAMEL-BIOMIMETICS
['FUNDING_R01'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-11128551
This study is looking at a protein called ameloblastin to see how it helps make and strengthen tooth enamel, using mice to learn more about how it works, which could lead to better treatments for dental issues that affect enamel.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-11128551 on ClinicalTrials.gov |
What this research studies
This research investigates the enamel protein ameloblastin and its role in the formation and mineralization of tooth enamel. By using advanced techniques like CRISPR-Cas9 gene editing in mouse models, the study aims to uncover how different parts of ameloblastin contribute to enamel structure and function. The research focuses on the interactions between ameloblastin and enamel-forming cells, which could lead to new insights into dental health and disease. Patients may benefit from a better understanding of tooth development and potential treatments for enamel-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with enamel defects or those at risk for dental caries.
Not a fit: Patients with fully developed and healthy enamel may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for dental conditions related to enamel formation and mineralization.
How similar studies have performed: Previous research has shown promising results in understanding enamel biomineralization, making this approach a continuation of established scientific inquiry.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OLDAK, JANET — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: OLDAK, JANET
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.