NIH-funded research R01 grant

Understanding how emotions and body responses predict substance use relapse after treatment

Official title: Interplay of Affect and Physiology in the Real-Time Prediction of Return to Use During Community Reintegration of Substance Users

Funded at University of Rhode Island · NIH-11077841 · Data updated 2026-11-12

This study is looking at how feelings and physical reactions affect people recovering from substance use disorder as they adjust back to everyday life, with the aim of finding ways to help them stay on track and avoid relapse during tough moments.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Rhode Island
NIH-funded
Lab location1 site (Kingston, United States)
Project startMay 1, 2024
Project endFebruary 28, 2029
Funding year2025
Award (this year)$696,828
NIH project number5R01DA058636-02
Project IDNIH-11077841 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals aged 21 and older who have recently completed residential treatment for substance use disorder.

Less likely to help

Patients who are not currently in recovery or those who have not undergone treatment for substance use disorder may not benefit from this research.

What this research studies

This research investigates the relationship between emotional states and physiological responses in individuals recovering from substance use disorder (SUD) during their reintegration into the community. By using daily monitoring techniques, such as ecological momentary assessment, the study aims to identify critical moments when individuals are at higher risk of returning to substance use. The goal is to develop tailored interventions that can be delivered in real-time to help prevent relapse, particularly focusing on managing emotional dysregulation. This approach seeks to enhance the support provided to individuals during the vulnerable period following their treatment discharge.

Why it matters

Potential benefit: If successful, this research could lead to more effective strategies for preventing relapse in individuals recovering from substance use disorder.

How similar studies have gone: Previous research has shown promise in using real-time monitoring and emotional regulation strategies to support individuals in recovery, indicating that this approach could be effective.

Where this research is happening

  • University of Rhode Island
    Kingston, United States
    Active

Researchers

  • Principal investigator: Weiss, Nicole Holland — University of Rhode Island
  • Study coordinator: Weiss, Nicole Holland

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.