Understanding how embryos develop asymmetrical organ placement.
Official title: Evolutionary mechanisms of gastrulation and left-right patterning in amniotes.
Funded at Stowers Institute for Medical Research · NIH-11062452 · Data updated 2026-11-12
This study is looking at how embryos, especially in chameleons, develop their organs on the right and left sides, which is really important for a healthy heart, and it aims to find out what helps these organs end up in the right spots.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stowers Institute for Medical Research NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $100,000 |
| NIH project number | 5K99HD114881-02 |
| Project ID | NIH-11062452 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with congenital heart defects or those interested in the genetic and developmental aspects of heart health.
✕Less likely to help
Patients with fully developed hearts and no history of congenital malformations may not receive direct benefits from this research.
What this research studies
This research investigates the biological processes that lead to the asymmetrical positioning of organs in embryos, which is crucial for proper heart development. By studying the mechanisms of left-right patterning in various species, particularly focusing on non-avian reptiles like veiled chameleons, the research aims to uncover how certain cellular movements and signals contribute to this process. The approach involves examining embryonic development in a controlled environment to identify key factors that influence organ placement and function.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for congenital heart malformations.
How similar studies have gone: Previous research has shown success in understanding left-right patterning in other species, but this specific approach using non-avian reptiles is relatively novel.
Where this research is happening
-
Stowers Institute for Medical Research
Kansas City, United States Active
Researchers
- Principal investigator: Shylo, Natalia — Stowers Institute for Medical Research
- Study coordinator: Shylo, Natalia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.