Understanding how embryos develop and close during formation
Morphogenesis: Biophysics and Genetics of Dorsal Closure
['FUNDING_OTHER'] · DUKE UNIVERSITY · NIH-11096093
This study is looking at how certain genetic changes affect the way embryos develop, using fruit flies to help us understand better, and the findings could help improve our knowledge of conditions like cleft palate.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11096093 on ClinicalTrials.gov |
What this research studies
This research focuses on the biophysics and genetics involved in the dorsal closure of embryos, a critical process in development. By utilizing advanced imaging technology, the team will analyze how genetic mutations affect this process in model organisms like Drosophila melanogaster (fruit flies). The study aims to replace outdated equipment to enhance the quality of time-lapse imaging, allowing for more precise observations of embryonic development. Patients may benefit from insights gained into genetic defects that can lead to conditions such as cleft palate.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic conditions affecting embryonic development, particularly those under 20 years of age.
Not a fit: Patients with fully developed conditions unrelated to genetic defects in embryonic development may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic factors influencing embryonic development and potential interventions for related congenital conditions.
How similar studies have performed: Other research in embryonic development has shown success using advanced imaging techniques, indicating that this approach is promising and builds on established methodologies.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIEHART, DANIEL PETER — DUKE UNIVERSITY
- Study coordinator: KIEHART, DANIEL PETER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.