Understanding how embryonic macrophages develop
Transcriptional basis of embryonic macrophage development
This study is looking at how special immune cells called macrophages, which help keep our tissues healthy, are made during pregnancy and how they continue to work in our bodies as we grow up, especially in places like the brain.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10654858 on NIH RePORTER |
What this research studies
This research investigates the development of tissue-resident macrophages, which play a crucial role in maintaining tissue health. It focuses on how these cells, derived during fetal life, are formed from progenitor cells in the yolk sac and fetal liver, rather than from adult bone marrow. By studying the transcriptional programs that guide their development, the research aims to uncover the mechanisms behind their persistence into adulthood and their functions in various tissues, including the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the biological mechanisms of immune cell development, particularly those with conditions influenced by macrophage function.
Not a fit: Patients with conditions unrelated to macrophage function or those who are not within the age range of embryonic development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how to manipulate macrophage development, potentially improving treatments for conditions related to tissue homeostasis and inflammation.
How similar studies have performed: Other research has shown success in understanding immune cell development, but this specific focus on embryonic macrophages is relatively novel.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Murphy, Kenneth M — Washington University
- Study coordinator: Murphy, Kenneth M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.