Understanding how Electroconvulsive Therapy affects depression and memory.
4/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
This study is looking at how Electroconvulsive Therapy (ECT) can help adults with major depression while also checking for any memory issues it might cause, so we can find the best way to use ECT safely and effectively for those who need it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11094934 on NIH RePORTER |
What this research studies
This research investigates the effects of Electroconvulsive Therapy (ECT) on adults with major depression, focusing on both its antidepressant benefits and potential cognitive side effects like memory loss. The study aims to develop standardized methods for administering ECT and to identify biomarkers that can predict patient responses and cognitive impacts. By integrating clinical assessments, neuroimaging, and advanced modeling techniques, the research seeks to optimize ECT dosing for maximum benefit while minimizing adverse effects. Patients will be closely monitored throughout the process to gather comprehensive data on their experiences.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing major depression and are considering ECT as a treatment option.
Not a fit: Patients who are not experiencing major depression or those who are not eligible for ECT may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved ECT protocols that enhance treatment outcomes for patients with major depression while reducing cognitive side effects.
How similar studies have performed: Previous research has shown promise in understanding ECT outcomes, but this study aims to take a novel approach by integrating multiple analytical methods to enhance understanding.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Mcclintock, Shawn M — Ut Southwestern Medical Center
- Study coordinator: Mcclintock, Shawn M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.