Understanding how electroconvulsive therapy affects depression and memory.
1/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
This study is looking at how electroconvulsive therapy (ECT) can help adults with major depression while also checking for any memory issues it might cause, and it aims to find the best way to give ECT so that you get the most relief from depression with the least side effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11094878 on NIH RePORTER |
What this research studies
This research investigates the effects of electroconvulsive therapy (ECT) on adults with major depression, focusing on both its antidepressant benefits and potential cognitive side effects like memory loss. The study aims to develop standardized methods for administering ECT and measuring its outcomes, using advanced techniques such as neuroimaging and EEG. By analyzing various biomarkers, the research seeks to identify the optimal ECT dosing that maximizes depression relief while minimizing cognitive impairment. Patients will be closely monitored to understand the mechanisms behind their responses to treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing major depressive disorder and are considering ECT as a treatment option.
Not a fit: Patients who are not experiencing major depression or those who are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved ECT protocols that enhance treatment outcomes for patients with major depression while reducing adverse cognitive effects.
How similar studies have performed: Previous research has shown promise in understanding ECT outcomes, but this study aims to take a novel approach by integrating multiple analytical methods to enhance understanding of both efficacy and safety.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Narr, Katherine L — University of California Los Angeles
- Study coordinator: Narr, Katherine L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.