Understanding how electroconvulsive therapy affects depression and cognitive side effects
3/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
This study is looking at how electroconvulsive therapy (ECT) can help adults with major depression while also checking for any memory issues it might cause, so we can find the best way to use ECT to lift your mood without affecting your memory too much.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11094755 on NIH RePORTER |
What this research studies
This research investigates the effects of electroconvulsive therapy (ECT) on adults with major depression, focusing on both its antidepressant benefits and potential cognitive side effects like memory loss. The study aims to develop standardized methods for administering ECT and measuring its outcomes, using advanced techniques such as neuroimaging and EEG. By analyzing various biomarkers, the research seeks to identify the optimal ECT dosing that maximizes antidepressant effects while minimizing cognitive impairment. Patients will be closely monitored to understand their responses and any adverse effects they may experience.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing major depressive disorder and are considering ECT as a treatment option.
Not a fit: Patients who are not experiencing major depression or those who are not eligible for ECT may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved ECT protocols that enhance treatment outcomes for patients with major depression while reducing cognitive side effects.
How similar studies have performed: Previous research has shown promise in understanding ECT outcomes, but this study aims to take a novel approach by integrating multiple analytical methods to enhance understanding of both benefits and risks.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Sheline, Yvette I — University of Pennsylvania
- Study coordinator: Sheline, Yvette I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.