Understanding how electrical stimulation affects non-neuronal cells in the brain
Elucidating electrical stimulation induced non-neuronal activity using emerging in vivo imaging technology and electrophysiology
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10894623
This study is looking at how gentle electrical stimulation affects certain brain cells that aren't neurons, to see how it might improve blood flow and overall brain health, which could help develop better treatments for neurological conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10894623 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of electrical microstimulation on non-neuronal cells in the brain, such as myeloid lineage and vascular smooth muscle cells. By using advanced imaging techniques and transgenic animal models, the study aims to explore how these cells respond to stimulation and how this impacts blood flow and tissue health over time. The goal is to uncover the mechanisms behind neuromodulation therapies, which could lead to better treatment strategies for various neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with neurological conditions that may benefit from electrical stimulation therapies.
Not a fit: Patients with acute neurological injuries or those not eligible for neuromodulation therapies may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the effectiveness of neuromodulation therapies, leading to improved treatment outcomes for patients with neurological disorders.
How similar studies have performed: Previous research has shown promising results in understanding the effects of electrical stimulation on neuronal activity, suggesting that this approach could yield valuable insights.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOZAI, TAKASHI DANIEL YOSHIDA — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: KOZAI, TAKASHI DANIEL YOSHIDA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.