Understanding how electrical signals control insulin release in diabetes and hyperinsulinism
Official title: KATP deficiency in hyperinsulinism and diabetes
Funded at Washington University · NIH-11059187 · Data updated 2026-11-12
This study is looking at how certain channels in the pancreas affect insulin release, which is important for people with conditions like hyperinsulinism and diabetes, and it hopes to find better ways to help manage these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 3, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $455,395 |
| NIH project number | 5R01DK133838-03 |
| Project ID | NIH-11059187 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with hyperinsulinism or type 2 diabetes who are experiencing challenges with insulin secretion.
✕Less likely to help
Patients with other forms of diabetes unrelated to insulin secretion issues may not benefit from this research.
What this research studies
This research investigates the mechanisms behind insulin secretion in conditions like hyperinsulinism and diabetes. It focuses on the role of KATP channels in pancreatic beta-cells, which are crucial for insulin release. By using advanced animal models, the study aims to explore how defects in these channels can lead to both excessive insulin production and eventual diabetes. The findings could lead to improved therapies for managing these conditions.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for patients with hyperinsulinism and diabetes, potentially improving their insulin management.
How similar studies have gone: Previous research has shown promising results in understanding KATP channels, indicating that this approach has potential for significant advancements in treatment.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Nichols, Colin G — Washington University
- Study coordinator: Nichols, Colin G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.