Understanding how electrical connections in the brain develop
Official title: Investigating the Molecular Mechanisms that Drive Electrical Synapse Development
Funded at University of Oregon · NIH-10906651 · Data updated 2026-11-12
This study is looking at how certain proteins help brain cells communicate with each other through special connections called electrical synapses, using zebrafish to learn more about these processes, which could eventually help people with neurological disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oregon NIH-funded |
| Lab location | 1 site (Eugene, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,068 |
| NIH project number | 5F31NS132555-02 |
| Project ID | NIH-10906651 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with neurological conditions that affect synaptic function.
✕Less likely to help
Patients with conditions unrelated to synaptic development or function may not receive direct benefits from this research.
What this research studies
This research investigates the molecular mechanisms that contribute to the formation of electrical synapses in the brain, which are crucial for neuronal communication. By studying proteins involved in these synapses, particularly focusing on Connexin proteins and other non-Connexin proteins, the research aims to uncover how these connections are established and maintained. The approach includes advanced imaging techniques and biochemical assays to analyze the interactions and functions of these proteins in neuronal circuits, particularly in zebrafish models. Patients may benefit from insights gained into the fundamental processes of brain function and potential implications for neurological disorders.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of brain connectivity, which may inform treatments for neurological diseases.
How similar studies have gone: Previous research has shown success in understanding synaptic mechanisms, but this specific focus on electrical synapses and non-Connexin proteins is relatively novel.
Where this research is happening
-
University of Oregon
Eugene, United States Active
Researchers
- Principal investigator: Kaye, Lila E — University of Oregon
- Study coordinator: Kaye, Lila E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.