Understanding how electrical connections form between specific neurons in the brain
Molecular mechanisms for neuron-specific assembly of electrical synapses
['FUNDING_R01'] · VANDERBILT UNIVERSITY · NIH-10830308
This study is looking at how certain brain cells connect with each other to help them communicate better, using tiny worms as a model, and it aims to understand the proteins involved in making these important connections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY (nih funded) |
| Locations | 1 site (Nashville, UNITED STATES) |
| Trial ID | NIH-10830308 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms that govern the assembly of electrical synapses, which are crucial for neuron communication and brain function. By using the C. elegans model organism, the study focuses on how specific neurons connect through gap junctions, which allow the flow of ions between them. The researchers will employ advanced genetic analysis and imaging techniques to explore the role of specific proteins and transcription factors in determining where these connections are made. This work aims to uncover the pathways that lead to the selective placement of electrical synapses in the nervous system.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that may involve synaptic abnormalities or those interested in the underlying mechanisms of brain function.
Not a fit: Patients with conditions unrelated to synaptic function or those who do not have access to the research facilities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into brain function and potential treatments for neurological disorders related to synaptic dysfunction.
How similar studies have performed: Previous research has shown success in understanding synaptic mechanisms in other models, but this specific approach to studying electrical synapses is relatively novel.
Where this research is happening
Nashville, UNITED STATES
- VANDERBILT UNIVERSITY — Nashville, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MILLER, DAVID M — VANDERBILT UNIVERSITY
- Study coordinator: MILLER, DAVID M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.