Understanding how electrical connections form between brain cells
Molecular mechanisms of electrical synapse formation in vivo
This study is looking at how certain genes and chemicals help brain cells communicate with each other through special connections called electrical synapses, using zebrafish to learn more about how problems in these connections might be linked to conditions like autism and epilepsy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oregon NIH-funded |
| Lab location | 1 site (Eugene, United States) |
| Project ID | NIH-11007201 on NIH RePORTER |
What this research studies
This research investigates the molecular pathways that regulate the formation of electrical synapses, which are crucial for communication between neurons. By using zebrafish as a model organism, the study aims to explore the genetics and biochemistry involved in the development and function of these synapses. The research focuses on how disruptions in these pathways may relate to conditions like autism and epilepsy, providing insights into the underlying mechanisms of these disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or related neurological conditions.
Not a fit: Patients with neurological disorders unrelated to synaptic function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions like autism and epilepsy by enhancing our understanding of neuronal communication.
How similar studies have performed: Previous research has shown promising results in understanding synaptic mechanisms, but this specific approach using zebrafish is relatively novel.
Where this research is happening
Eugene, United States
- University of Oregon — Eugene, United States (Active)
Researchers
- Principal investigator: Miller, Adam C — University of Oregon
- Study coordinator: Miller, Adam C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.