Understanding how electric stimulation affects brain activity
Cellular and Neural Network Mechanism of Transcranial Electric Stimulation
This study is looking at how a gentle brain stimulation technique called transcranial electric stimulation (TES) might help improve brain activity and behavior, especially for people with epilepsy, by enhancing communication between brain cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10619434 on NIH RePORTER |
What this research studies
This research investigates how transcranial electric stimulation (TES), a non-invasive technique, can influence brain activity and behavior. By using advanced imaging techniques and genetic models, the study aims to uncover the mechanisms behind TES, particularly focusing on a phenomenon called ephaptic coupling, which may enhance neural communication. The research will explore how TES can modulate seizure activity and cognitive functions, potentially leading to new treatments for neurological disorders. Patients may benefit from a better understanding of how TES can be used to improve brain function and manage conditions like epilepsy.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with epilepsy or cognitive disorders who may benefit from neuromodulation therapies.
Not a fit: Patients with conditions unrelated to brain function or those who do not respond to electrical stimulation therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for seizure control and cognitive enhancement using non-invasive brain stimulation techniques.
How similar studies have performed: Previous research has shown promise in using electrical stimulation for various neurological conditions, but the specific mechanisms of TES are still being explored, making this a novel investigation.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Durand, Dominique M — Case Western Reserve University
- Study coordinator: Durand, Dominique M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.