Understanding how elastin loss affects heart and blood vessel health
Official title: Epigenetic-mediated Notch pathway activation promotes elastin aortopathy
Funded at Yale University · NIH-11013367 · Data updated 2026-11-12
This study is looking at supravalvular aortic stenosis (SVAS), a heart condition caused by too much growth of smooth muscle in the arteries, and it aims to understand how a specific signaling pathway is involved when a protein called elastin is missing, with hopes of finding new ways to help people with SVAS.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $654,729 |
| NIH project number | 5R01HD110059-03 |
| Project ID | NIH-11013367 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with supravalvular aortic stenosis or those with Williams Beuren Syndrome.
✕Less likely to help
Patients without a diagnosis of SVAS or related cardiovascular conditions may not benefit from this research.
What this research studies
This research investigates supravalvular aortic stenosis (SVAS), a condition that leads to heart and blood vessel problems due to excessive growth of smooth muscle cells in the arteries. The study focuses on the role of the Notch signaling pathway in this process, particularly how it is activated when elastin, a key protein in blood vessels, is deficient. By using animal models, the researchers aim to uncover the molecular mechanisms that contribute to this condition and explore potential therapeutic targets to prevent or reduce the severity of SVAS.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent heart failure and improve outcomes for patients with SVAS.
How similar studies have gone: Previous research has shown promising results in understanding the role of the Notch pathway in cardiovascular diseases, indicating that this approach may yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Greif, Daniel — Yale University
- Study coordinator: Greif, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.