Understanding how eggs eliminate extra chromosomes during cell division
Mechanisms of asymmetric cell division during female meiosis
This study looks at how certain cells in female reproduction, specifically in a tiny worm called C. elegans, carefully get rid of extra chromosomes to make sure only the right amount goes into the egg, and by understanding this process, we hope to learn more about problems in human reproduction that can cause serious conditions like trisomy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11010282 on NIH RePORTER |
What this research studies
This research investigates the process of asymmetric cell division during female meiosis, where a significant portion of chromosomes is eliminated to ensure that only a quarter are passed on to the egg. By studying the model organism C. elegans, the research aims to uncover the molecular mechanisms behind this selective chromosome elimination. The findings could provide insights into errors in human meiosis that lead to conditions like trisomy, which can result in severe developmental issues. The approach involves advanced techniques such as chromatin conformation capture to analyze chromosome behavior during cell division.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals or couples experiencing recurrent pregnancy loss or chromosomal abnormalities in their offspring.
Not a fit: Patients who do not have a history of chromosomal abnormalities or reproductive issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for chromosomal abnormalities in human reproduction.
How similar studies have performed: Previous research has shown success in understanding meiotic processes in model organisms, suggesting that insights gained could be applicable to human health.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Mcnally, Francis J — University of California at Davis
- Study coordinator: Mcnally, Francis J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.