Understanding how egg cells form and organize their spindles during division
Mechanisms underpinning meiotic spindle formation and behavior
This study is looking at how egg cells organize their structures to properly separate chromosomes during the process of making eggs, which could help us understand some of the challenges women face when trying to get pregnant due to chromosome issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-10909943 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the formation and behavior of meiotic spindles in female egg cells. It focuses on how these spindles, which are crucial for proper chromosome segregation, are organized without the traditional centrosomes found in other cell types. The study aims to uncover the roles of microtubule organizing centers and F-actin in this process, which could help explain difficulties in achieving pregnancy related to chromosomal abnormalities. By using advanced imaging techniques, the research seeks to provide insights into the cellular dynamics during meiosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are women experiencing difficulty conceiving, particularly those with a history of chromosomal abnormalities.
Not a fit: Patients who are not seeking to conceive or who do not have any chromosomal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for infertility caused by chromosomal issues.
How similar studies have performed: While the specific mechanisms being studied are novel, previous research has shown that understanding cellular division processes can lead to significant advancements in reproductive health.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Balboula, Ahmed — University of Missouri-Columbia
- Study coordinator: Balboula, Ahmed
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.