Understanding how egg and sperm proteins interact during fertilization
Integrating 'omics', evolution, and biochemistry to understand fertilization
This study looks at how certain proteins from eggs and sperm work together to help fertilization in abalones, which could help us understand why some people have trouble getting pregnant.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10906246 on NIH RePORTER |
What this research studies
This research investigates the interactions between egg and sperm proteins that are crucial for fertilization, using the marine gastropod abalone as a model organism. By identifying specific proteins involved in these interactions, the study aims to uncover the mechanisms that may lead to infertility in humans. The research employs advanced biochemical techniques to analyze protein structures and their functions, focusing on how mutations may affect fertility. Ultimately, the goal is to provide insights that could help address unexplained infertility cases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals or couples facing infertility issues, particularly those with no known cause for their difficulties in conceiving.
Not a fit: Patients who have identified causes of infertility unrelated to protein interactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating infertility in couples experiencing unexplained reproductive challenges.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown success in understanding reproductive protein interactions in other species, suggesting potential for breakthroughs in human fertility.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Wilburn, Damien Beau — Ohio State University
- Study coordinator: Wilburn, Damien Beau
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.