Understanding how EGF receptor signaling affects tumor growth
Intrinsic Disorder and Agonist Bias in EGF Receptor Signaling
This study is looking at a protein called the EGF receptor, which can be changed in certain tumors like glioblastoma, to understand how it helps tumors grow, with the hope of finding better treatments for patients facing these tough cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10768568 on NIH RePORTER |
What this research studies
This research investigates the EGF receptor, a protein that is often mutated in various tumors, including glioblastoma. By examining how this receptor interacts with other proteins in the cell, the study aims to uncover the mechanisms that drive tumor growth and progression. The researchers will use advanced computer modeling and biochemical techniques to explore how different regions of the receptor influence its signaling pathways. This could lead to new insights into how to better target therapies for patients with aggressive tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma or other tumors that exhibit mutations in the EGF receptor.
Not a fit: Patients with tumors that do not involve the EGF receptor or those with early-stage tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with glioblastoma and other tumors associated with EGF receptor mutations.
How similar studies have performed: Previous research has shown promising results in targeting EGF receptor signaling in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Pike, Linda Joy — Washington University
- Study coordinator: Pike, Linda Joy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.